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Role in tumorigenesis The two main factors leading to this are metabolic recurrence and chemoresistance

Its epidemiology shows marked geographic variation: incidence is highest in North America and Western Europe (920 cases per 100,000 person-years) but is rising rapidly in regions historically considered low risk, including parts of Asia and South America ( Pharmacologic management of UC aims to control inflammation and induce and maintain remission

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Researchers achieved attenuation by knocking out the msbB and purI genes and introduced a human IL-2 expression cassette, aiming to achieve tumor-selective colonization and local immune activation while minimizing systemic toxicity