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In yet another embodiment, the one or more agents that down-regulate the copy number, amount, and/or activity of at least one target listed in table 1 and/or table 2 is a small molecule inhibitor, a CRISPR guide RNA (grna), an RNA interfering agent, an antisense oligonucleotide, a single-stranded nucleic acid, a double-stranded nucleic acid, an aptamer, a ribozyme, a dnase, a peptide, a peptidomimetic, an antibody, an intracellular antibody, or a cell

Protein Ss half life is longer, somewhere on the order of factor II (although factor IIs is still longer)

What are the potential concerns regarding long-term use of celecoxib

More severe cases might take longer and full recovery might not be possible