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Compared with traditional pharmaceuticals used to combat skin aging, natural bioactive substances have emerged as promising alternatives because of their reduced side effects and diverse biological activities (18, 19)

Consequently, there has been a steady rise in the prevalence of asthma, with an estimated global population of approximately 400 million individuals affected by the condition by the year 2025

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In addition, cellular and molecular studies focused on understanding the GBM microenvironment, especially in the aggressive peripheral regions, provide a wealth of information for the design of specific nanotherapeutics