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Moreover, most clinical trials continue to rely on liver enzymes and imaging endpoints without stratifying patients according to inflammatory phenotype or cytokine signatures

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Although Free T3 rises earlier in hyperthyroidism than Free T4 and is thus a more sensitive test, levels are particularly susceptible to non-thyroidal influences which alter peripheral T4 to T3 conversion

Hippocampal and hypothalamic sections from PTZ-treated animals were characterized by severe histopathological alterations and, intensely, increased the ezrin immunolabeled astrocytes