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El Sahly says that it only happens in a small fraction of people

For instance, copper deficiency severely reduces cytochrome c oxidase activity affecting copper/zinc-superoxide dismutase to a lesser extent (66)

But for others, there are many non-allergic symptoms

Notably, currently available therapies for RA, such as cytokine (TNF and IL-6) blockers or inhibitors of the JAK-STAT pathway 43 , exclusively tackle the inflammatory phase of the disease but do not interfere with the underlying processes that initiate the onset of arthritis and therefore often need to be given life-long 44