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For example, eight Australian families with Lebanese ancestry diagnosed with LS or LS-like encephalopathy associated with COX deficiency had mutations in the PET100 gene (Lim et al., 2014)

In the animal studies, Alsayadi et al

Cell death by ferroptosis is genetically prevented by the lipid repair enzyme glutathione peroxidase 4 (GPX4), which converts lipid hydroperoxides to unreactive lipid alcohols [17]