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Also, downregulation of interferon stimulated genes such as MX1, IFITM1, and IFIT2 were observed in critical COVID-19 cases, as well as undetected messenger RNA levels of IFN- in blood (123)

Howland DS, Trusko SP, Savage MJ, Reaume AG, Lang DM, Hirsch JD, Maeda N, Siman R, Greenberg BD, Scott RW, Flood DG (1998) Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol

The secondary endpoints include achievement of 20% weight reduction, relative change in body weight, change in waist circumference, change in HbA1c, change in systolic blood pressure, change in the quality of life (IWQOL-Lite-CT), and change in short-form physical functioning score (SF-36v2)

Anti-inflammatory and antioxidant agents, inhibitors of TECs G2/M arrest, pro-angiogenic factors, epigenetic therapies, tissue regeneration promoters, and fibrosis inhibitors are being explored (Fig