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A similar study also indicated that CUR decreases the gene expression of SP-1 and lowers its trans-activation function, a process facilitated by the activation of PPAR

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However, in an agonist-bound state such as was seen in the crystal structure of DHT-bound AR (PDB: 1I37 or 2AMA), H12 was held near H3 and H4 (Figure 3D)