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So, these agents target the underlying pathophysiology of PD, unlike traditional symptomatic treatments like MAO-B inhibitors, dopamine agonists, or COMT inhibitors

The vascular capillary leakages of proteins like thrombin, IgG, fibrinogen, albumin, and hemosiderin in the hippocampus and prefrontal as well as entorhinal cortex of the AD patients have been observed

Even though other relevant options are available, such as animal models or ex vivo models, in vitro models offer higher experimental flexibility and reproducibility, making them a valuable tool for the understanding of pathophysiological mechanisms of several diseases, such as CVDs

Oncol., 111: 133-136