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Glutathione depletion and susceptibility

Functionally, zone 1 hepatocytes are specialized for oxidative liver functions such as gluconeogenesis, b-oxidation of fatty acids, and cholesterol synthesis, while zone 3 cells are more important for glycolysis, lipogenesis, and cytochrome P-450based drug detoxification

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Hydrogen sulfide (H 2 S), a gaseous signaling molecule, plays various roles such as neuronal transmission, smooth muscle relaxation, and cell protection against oxidative stress