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Numerous studies have indicated that leptin, a crucial hormone involved in the regulation of energy balance and BMI, may be involved in MDD

Notably, red wine polyphenol extract has been shown to efficiently suppress the inflammation of intestinal epithelial cells by inhibiting JAK/STAT and promoting Nrf2 pathways (116)

Further studies of the PNPLA3 polymorphism in the context of NASH in humans and its mechanism of action are required, to confirm whether murine models with this genetic mutation are good preclinical models of NASH