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The authors found that a 14 day course of treatment with metronidazole given to healthy dogs, resulted in significant changes in microbiome composition, including severely decreased amounts of a key beneficial bacteria, Fusobacteria

Results showed that switching patients who were stable on warfarin to a DOAC caused more bleeding complications compared to staying on warfarin, without an associated reduction in strokes or clots

Given their non-invasive nature and similar clinical performance, these routes may represent suitable alternatives to intramuscular therapy, particularly in settings requiring long-term management

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