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Prolonged inflammation induces key kinases, p38 and GSK-3 Prolonged inflammation activates histone deacetylases Prolonged inflammation contributes to oxidative damage via dysregulation of Nrf2 Acknowledgments This research received financial assistance from the Swedish Research Council (VR2009-2630, 2012-2992), a Government grant to a researcher in Public Health Service at the Sahlgrenska University Hospital (ALFGBG-142881), European Union grant FP7, (Neurobid, HEALTHF2-2009-241778), the Leducq foundation (DSRR_P34404), hln-stiftelsen, Wilhelm and Martina Lundgren Foundation, Swedish Brain Foundation (FO2013-095) and the National Institutes of Health (R01 GM044842)

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Consequently, 59.8% and 49.3% of cases were missed