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It is well demonstrated that widely used biguanide drug metformin, known for reducing blood glucose levels, also demonstrates the inhibitory effect at the early, intermediate, and late stages of glycation, and induces glyoxalase I activity, thereby reducing the level of -dicarbonyl compounds and AGEs (120, 142, 143)

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Treatment, follow-up, and prognosis of patients with WD hepatic type Fifteen patients were lost to follow-up, and the average follow-up time for the remaining 33 patients was 48.6 months (1272 months)

Metabolites 12(6):527 Chen T et al (2023) Methylmalonic acidemia: Neurodevelopment and neuroimaging