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ADC: antibody-drug conjugate APC: activated protein C asTF: alternatively spliced tissue factor BiTEs: bispecific T cell engagers CARs: chimeric antigen receptors COX: cyclo-oxygenase CRC: colorectal cancer CTCs: circulating tumor cells DFS: disease-free survival DOACs: direct oral anticoagulants EC: endothelial cell ECM: extracellular matrix EGF: epidermal growth factor EMT: epithelial-mesenchymal transition FDPs: fibrin degradation products FVII: factor VII FVIIa: activated factor VII GP: glycoprotein GPCRs: G protein-coupled receptors HER2: human epidermal growth factor receptor 2 HMWK: high molecular weight kininogen HR: hazard ratio JAK: Janus-associated kinase LMW: low molecular weight LRP-1: lipoprotein receptor-related protein-1 MAPK: mitogen-activated protein kinases MHC: major histocompatibility complex MMAE: monomethyl auristatin E MMPs: matrix metalloproteinases mTOR: mammalian target of rapamycin NK: natural killer OPN: osteopontin OS: overall survival PAF: platelet-activating factor PAI-1: plasminogen activator inhibitor-1 PARs: protease-activated receptors PAs: plasminogen activators PDGF: platelet-derived growth factor PDPN: podoplanin PI3K: phosphatidylinositol 3-kinase ROC: receiver operating characteristic RTK: receptor tyrosine kinase STAT: signal transducer and activator of transcription TAFI: fibrinolysis inhibitor TCIPA: tumor cell-induced platelet aggregation TF: tissue factor TFPI: tissue factor pathway inhibitor TGF-: transforming growth factor- tPA: tissue-type plasminogen activator TV: tisotumab vedotin uPA: urokinase-type plasminogen activator uPAR: urokinase-type plasminogen activator receptor VEGF: vascular endothelial growth factor VTE: venous thromboembolism VWF: von Willebrand factor OOI: Conceptualization, Investigation, Writingoriginal draft, Writingreview & editing, Validation, Supervision

How long until I notice anything

References Journal of Endocrinology and Metabolism (2014) Safety and metabolism of AOD9604 as a nutraceutical ingredient

Some patients never experience visible bruising despite months or years of weekly injections, while others notice small bruises regularly