glutathione high or low in acetaminopen overdose usmle USMLE® Step 2 CK Question of the Day: Altered Mental State After “Over-the-counter pain reliever” and Prescription Hydrocodone-acetaminophen Too much paracetamol = dangerous
Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Overdose of acetaminophen most likely results in hepatic necrosis due to depletion of glutathione What substance depletion causes hepatic necrosis from acetaminophen overdose ? Acetaminophen MSK Medbullets Step 1
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