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Pembrolizumab and nivolumab which have also been in a category of immune checkpoint inhibitors are approved by FDA as a first line therapy in patients having cisplatin insensitive recurrent or metastatic HNSCC [19,20,21]

Prediction of the physicochemical properties of the main ingredients of the Chinese herbal medicine Fibraurea recisa Pierre PubChem ( ADMETlab 2.0 (Su et al., 2007): A website for predicting the physicochemical properties of compounds, the ADME properties, and the toxicity correlations