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Research has investigated the mechanisms by which NNMT inhibition might increase energy expenditure, potentially through effects on mitochondrial function or uncoupling protein expression

Images corresponding to each sample were averaged to obtain the mean adipocyte area ( m2) per sample and combined to calculate group mean values for control (vehicle-treated EWAT samples) and treatment (NNMT inhibitor-treated EWAT samples) cohorts

If two formulations are otherwise identical except for B12 form, the methylcobalamin version will be more expensive

The remaining 25 articles were included in the qualitative synthesis, and 16 in the quantitative synthesis (Figure 1)