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Both 5AC and decitabine undergo phosphorylation prior to incorporation into DNA but 5AC additionally incorporates into RNA, which generates the main difference between the two drugs

doi: 10.1562/2006-01-30-RA-787 11

A.NabiG.SharmaS

A major challenge in cancer immunotherapy is T cell exhaustion, when the immune system's cancer-fighting cells become too fatigued to keep attacking tumors