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At the same time, reduced IDO activity reduced kynurenine and further weakened peripheral immune tolerance, which played a driving role in the hypothyroidism immune disorder caused by the imbalance of the whole gut microbiota (Clarke et al., 2017)

(2017) optimized fermentation conditions via response surface methodology and found that critical parameters (e.g., pH 7.79 and enzyme concentration 2.73%) must be precisely matched to strain characteristics to avoid significant reductions in extraction efficiency

Kojic Acid vs Vitamin C for Hyperpigmentation: Which Actually Wins