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Discussion rhGH studies on ISS have focused on childhood or on the beginning of puberty [2, 7, 1218, 20, 33, 3752], with the belief that a younger age favors rhGH effects [37]

demonstrated an inverse correlation between childhood gut microbiota diversity and susceptibility to asthma/allergic conditions, implicating depauperate microbiota as a potential risk amplifier ( Lactobacillus , alongside pathobiont enrichment such as Escherichia colia microbial signature that may perpetuate inflammatory cascades (Li et al., 2022b)

In this regard, recent studies have shown that dietary practices, sleep time, and level of PA in children aged 6-12 years living in the Pacific Region play a significant role in the development of overweight and obesity

Intraoperative direct cortical stimulation or implanted epidural stimulators in the precentral gyrus have also shown clinical efficacy with transient disappearance of severe parkinsonism in some cases 98 or long-lasting improvements in motor symptoms in some studies 97