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In one embodiment, the proliferation of a cell expressing ALPP/ALPPL2 or a fragment thereof (e-g, a cancer cell) may be decreased by at least 10%, or at least 20%, or at least 30%, or at least 40%, or at least 50%, or at least 60%, or at least 70%, or at least 80%, or at least 90%, or 100%) when the cells are contacted with the antibody or antigen binding portion thereof or an immunoconjugate described herein, relative to the proliferation measured in the absence of the antibody or antigen binding portion thereof or immunoconjugate (control)

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Matrixyl, or Palmitoyl Pentapeptide-4, is not a neuromodulator but is often included in Botox-like formulations because it boosts collagen production and enhances firmness

Several of these compounds have progressed to clinical evaluation, known for their potency and selectivity as a GlyT1 inhibitor, progressed to phase II clinical trials, particularly focusing on schizophrenia aimed at assessing their efficacy as an adjunctive therapy for negative symptoms in schizophrenic patients receiving concurrent antipsychotic treatment, but these trials were discontinued several years ago due to unspecified safety concerns (Javitt et al