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The unreported variants were classified according to the American College of Medical Genetics (ACMG) criteria [32]

Therefore, we examined whether carnitine deficiency was associated with exercise inactivity in HD subjects

This metabolic alteration has been associated with metabolic diseases or to insulin deficiency 62,63,64

Recent drug discovery strategies are based on two criteria: first, compound structures that are distinct from bicalutamide and enzalutamide to avoid cross-resistance and, second, compounds that retain antagonist properties even for known AR mutant proteins that adopt agonist conformations when bound to current AR antagonists (also known as pan-antagonists)