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The use of dehydroalanine (Dha) in a peptide sequence provides an ideal target for Michael addition, and has been demonstrated as a handle for peptide modification (Zhu and van Der Donk, 2001

Recent investigations have further elucidated that histone lactylation augments ALKBH3 expression, while simultaneously attenuating the formation of promyelocytic leukemia protein (PML) condensates, a tumor suppressor, and exacerbating malignant transformation through the removal of m1A methylation in SP100A, thereby facilitating cancer progression (147)