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MOTS-C OVERVIEW Category: Mitochondrial-Derived Peptide, Metabolic Regulator, Exercise Mimetic How It Works: MOTS-c is a peptide that regulates gene expression related to metabolic homeostasis and cellular stress

For instance, when intra-portal insulin levels are increased [e.g., obesity, Cushings syndrome or due to treatment with glucocorticoids and glucagon-like peptide-1 receptor agonists (GLP-1RA)] or decreased (e.g., anorexia nervosa and T1D) in disease states, these secondary changes (secondary association) alters hepatic GH sensitivity resulting in discordant GH and IGF-I levels (high GH/low IGF-I levels and low GH/high IGF-I levels, respectively)

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