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This work was supported by the National Key Research and Development Program of China (2020YFA0908400 to S.W.), the Distinguished Young Scholars of Hubei Province (2022CFA078 to S.W.), the Knowledge Innovation Program of Wuhan-Shugung Project (2023020201020418 to S.W.), the Young-Thousands Talents Program and the National Natural Science Foundation of China (32371344 to H.R.), as well as the startup funding from LSI, Zhejiang Key Laboratory of Molecular Cancer Biology at Zhejiang University

Assessment and diagnostic process The main challenge to correctly establish mitochondrial dysfunction as the cause of the presentation of a specific patient is the absence of a definitive biomarker that characterizes mitochondrial disease in all patients

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