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This axis offers a theoretical basis for developing interventions that may slow disease progression, though its ability to achieve meaningful clinical benefit remains contingent on addressing unresolved scientific and translational challenges

(PMC) A separate metabolism-focused paper reviewing human trial history makes a similar point: early signals of weight loss were not consistently reproduced in later studies, particularly when intensive diet/exercise protocols were included

: Neue archologische Ausgrabungen in der eisenzeitlichen Siedlung von Welschingen, Flur Guuhaslen, in: Archologische Ausgrabungen in Baden-Wrttemberg 2014, 120123, 2015

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