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Although efficient, these approaches provide limited local delivery and substantial systemic exposure, restricting their clinical applicability

6.5.1 Dosing regimens The dosing regimen for N-acetylcysteine (NAC) varies depending on the route of administration, with both intravenous and oral formulations available

Its supported by multiple lines of evidence, and illustrates precisely why the gut-immune axis matters in the real world

Outside the CNS, serotonin is produced in the ENS and released predominantly by enterochromaffin cells (estimated to be up to 90% of the body's serotonin production [169]) of the gut mucosa and immune cells, with influence not only on the ENS but also on the CNS via the GBA [283]