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doi: 10.1016/0896-6273(92)90167-C 34 BivilleF.BrzillonC.GiorginiD.TahaM.-K

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Data suggests a short half-life and bioavailability of about 30% due to certain mechanisms, including hepatic degradation, reduced solubility as well as instability in the stomach [91]

Specifically, the drug resistance mechanisms of HGSOC are primarily manifested in tumor cell heterogeneity, which leads to significant differences in drug response among various cell subpopulations