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Clonal selection may facilitate the initial survival of malignant cells during anticancer therapy, permitting a minority of cancer cells to acquire additional drug-resistant mutations, thereby facilitating disease progression

At that time, some patients, often those with obesity, diabetes, or both, confronted medical skepticism by insisting on their minimal alcohol consumption

The inevitable presence of epigenetic variation inherent to humans, which can influence symptom presentation, disease onset, response to therapy, and other aspects of pathophysiology, is another challenging consideration in human disease research and management (Levin et al., 2022)

Nature 507 , 248252, doi: 10.1038/nature12920 (2014)