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Nervonic acid attenuates accumulation of very long-chain fatty acids and is a potential therapy for adrenoleukodystrophy

The term "non-targeted therapy" refers to the administration of an agent that does not selectively interact with a selected biomolecule but still treats cancer

It is not a substitute for professional medical advice

Under normal oxygen conditions, HIF-1 and endothelial PAS domain-containing protein 1 (EPAS1, HIF-2) are hydroxylated by the prolyl hydroxylase EGLN (EGLN) family members and then recognized and degraded by E3 ubiquitin ligase, von Hippel-Lindau disease tumor suppressor (VHL)