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It was noted that there were 80 reported positive test doses, and given the high positive predictive value of the test dose, it is possible that many cases of LAST were avoided

Such ligand-induced dimerization model has been observed in the activation of c-MET by a bacterial c-MET agonistInlB 31 , as well as in the activation of many other RTKs, such as PDGFR and VEGFR 32,33

Current areas of scientific investigation include cellular repair signaling studies, connective tissue pathway analysis, extracellular matrix regulation research, copper-dependent signaling investigations, peptide interaction and pathway convergence studies, and multi-peptide coordination research

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