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Bhowmick N, et al

and Martnez-Sena et al., evaluated whether the analysis of the impact on a set of metabolic pathways could constitute a characteristic metabolic fingerprint of the different hepatotoxicity mechanisms ( p -value), and the impact factor (estimated as the sum of the importance measures of all metabolites in the pathway) were used as k descriptors (i.e., coordinates) of the metabolic pathway outcome (Figure 6)