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These subsequent injuries involve the disturbance of the blood-brain barrier (BBB), excitotoxicity induced by glutamate, oxidative stress, and neuroinflammation, all of which can develop in a time-dependent manner following the initial mechanical injury ( One key goal of therapeutic management after the trauma is to manage or reduce the progression of SIC

On the other hand, it is also essential that brain organoids show specific functions (2), such as synaptic function

Purification and characterisation of NAD-glutamate dehydrogenase from Aspergillus nidulans