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The recent review by Mao (1), discussed the bioactive compound and bioactivities of ginger, including antioxidant activity, anti-inflammatory activity, antimicrobial activity, neuroprotection, anti-obesity activity, anti-diabetic activity, protective effect against respiratory disorders, also the other bioactivities of ginger (hepatoprotective and antiallergic effects) (1)

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123 Transforming growth factor-beta (TGF-) and vascular endothelial growth factor (VEGF) secreted by these M2 macrophages support tissue repair, collagen synthesis, and angiogenesis, guiding the joint toward structural and functional restoration