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109, 110 Acute or chronic treatment with antioxidants or superoxide dismutase not only improved endothelial dysfunction but also markedly reduced blood pressure, indicating the potential role of ROS in the initiation and maintenance of hypertension

doi:10.1177/0269881106063042

TGF- upregulates several NOX isoforms particularly NOX1, NOX2, and NOX4 in multiple cell types

The absence of tumor-promoting findings in peer-reviewed animal research is reassuring but not definitive, as longer-duration or tumor-specific experiments testing BPC-157 in oncological models are not present in the published literature