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Crucially, recent evidence reveals that a ROS-EMT axis creates a physical immune-privileged niche by remodeling the extracellular matrix to exclude T cells, thereby linking oxidative stress directly to immune evasion [112, 113]

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Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

The course of BD is also intensified by other comorbid psychiatric disorders [14] such as anxiety disorders [15], attention deficit hyperactivity disorder (ADHD) [16], alcohol use disorder (AUD), substance use disorder [17], and binge eating disorder [18], as well as cognitive impairment [19], implying a potential intersection of their pathogenesis