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Natural products are garnering heightened attention in the investigation of BBB permeability modulation

FEBS J 277:50865096 Mandal PK, Ersland L (2019) Editorial: Predictive imagable biomarkers for neurodegenerative and neurodevelopmental diseases

Nagakura, Y., Ito, H

however, in CPB-related studies, bradykinin levels have, to a large extent, been shown to be elevated (59), probably because CPB bypasses the lung tissue (where bradykinin is inactivated)