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In this longitudinal study, they determined that at baseline the expression of Nrf2 and Nrf2-related genes (heme oxygenase (HO)-1 and glutamate-cysteine ligase catalytic (GCLC) subunit) in PBMCS was significantly increased in COPD compared to no-COPD subjects, whereas at the follow-up (49.7 6.9 months) the expression was significantly decreased in COPD which worsened over that time, while no changes were observed in no-COPD subjects

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At the root of this deterioration of physical fitness is damage to mitochondria, the cells powerhouse, and, ultimately, cells caused by oxidative stress the buildup of harmful, oxygen-containing molecules and lack of antioxidants

E.TeutonicoR