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Side effects were mainly mild-to moderate gastro-intestinal symptoms (nausea, vomiting, diarrhoea) mostly occurring with higher doses of retatrutide and with faster titration (Table 2)

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Guideline Statement 12 Appropriate manual physical therapy techniques (e.g., maneuvers that resolve pelvic, abdominal and/or hip muscular trigger points, lengthen muscle contractures, and release painful scars and other connective tissue restrictions), if appropriately trained clinicians are available, should be offered to patients who present with pelvic floor tenderness

They might provide other health advantages, but its important to balance these against any possible drawbacks