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Scleral cross-linking by riboflavin and blue light application in young rabbits: damage threshold and eye growth inhibition

Research demonstrates that NNMT expression increases significantly with advancing age, particularly in metabolic tissues, contributing to the progressive decline in NAD+ levels observed during aging

Since this process also appears to be regulated via a negative feedback mechanism, the ancillary impacts typically associated with excessive growth hormone production appear to be avoided

It works by inhibiting the activity of NNMT (nicotinamide N-methyltransferase) , an enzyme linked to fat cell metabolism and NAD depletion