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In cold blooded vertebrates, dendritic spines have been described in Xenopus olfactory bulb interneurons (Zhang et al., 2016) and in tectal interneurons of the jewel fish (Coss and Globus, 1979)

A dedicated phase 2a substudy in people with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) used MRI to measure liver fat and found that, after 24 weeks, retatrutide reduced relative liver-fat content by about 81% at the 8 mg dose and about 82% at 12 mg, versus essentially no change on placebo

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