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Tornehave, et al (2008)

Older Adults and Anti-Aging Seekers As we age, growth hormone levels naturally decline , contributing to signs of aging such as: Decreased muscle mass Increased body fat Weakened bones and joints Wrinkled, sagging skin Ipamorelin can help combat these effects by: Boosting GH production Supporting bone density and joint lubrication Improving skin elasticity and collagen formation Enhancing sleep quality and recovery For aging individuals, it offers a natural, well-tolerated alternative to synthetic hormone therapies

Li et al (76) found that the percentages of the apoptotic cells for HCT116 cells increased from 4.7-35.2% in the control group and the Polyphyllin II treated group (4 M) and for SW620 cells from 4.6-27.3% in the control group and the Polyphyllin II treated group

That mechanism is why clinicians reach for it first for age-related GH decline: energy, sleep quality, recovery, and body composition are the common goals