is l glutamine a precursor to glutathione 5 Route of synthesis of (GSH) involving three amino acids l glutathione l glutamine l

The anticancer activity of this compound is related to its pro-oxidant and antioxidant capacity due to its complex structure including double bond in the carbonic chain, the position and number of OH group and free phenolic hydroxyl in the catechol group, respectively (Kiokias et al., 2020)

RSL3 is known to interact with thioredoxin reductase 1 (Txnrd1) which also plays a role in DNA damage and oxidative stress 31

FIGURE 1 Exogenous ROS Environmental triggers, such as exposure to cigarette smoke, UV radiation, heavy metal ions, ozone, allergens, drugs or toxins, pollutants, pesticides, or insecticides, may all contribute to the increase of ROS production in cells (Mahajan et al., 2018

Takai et al