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Therefore, restriction of NEAAs, such as serine, glycine, and asparagine, in the tumor microenvironment can effectively inhibit tumorigenesis of NRF2-addicted cancer cells

The efficiency of the proteomic approach has gained considerable attention for identifying various industrially important enzymes, stimulating its use in the discovery of novel nitrilase-metabolizing enzymes ( 5.1 Conventional culture-dependent approach The conventional culture-dependent approach includes the isolation of natural nitrilase/amidase-producing microorganisms that hydrolyse 3-cyanopyridine/nicotinamide into nicotinic acid and optimization of the conditions for nicotinic acid synthesis (Table 1)