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While useful for measuring small intestinal permeability, lactulose, mannitol and L-rhamnose are all fermented by the gut microbiota when they reach the colon and are thus unreliable for the assessment of specifically colonic permeability

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Overall, the consistent finding of elevated lipid peroxidation markers across various studies and sample types provides robust evidence of heightened oxidative stress in CF, contributing to cellular dysfunction and disease progression

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