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Key Takeaway: Combining NAC and glutathione allows for both immediate antioxidant support and long-term internal production, helping the body manage oxidative stress more effectively than using one alone

Identification of ferroptosis genes in MYCN -amplified cells To systematically identify the cellular vulnerabilities associated with high MYCN expression, we performed an unbiased synthetic lethal small interfering (siRNA) screen using high/low MYCN IMR5/75 cells (Fig