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Over the past decade, the number of patients with ORN has doubled

Furthermore, epigenetic dysregulation has been described in neurodegenerative models, including alterations in chromatin structure and histone acetylation that influence gene expression linked to metabolic stress responses and neuronal survival [9]

2017b )

Currently, there is an increasing focus on therapeutic strategies targeting the side branches of glycolysis, especially the serine/glycine (ser/gly) synthesis pathway, since it is upregulated in approximately 30% of all cancers, including GBM [21]