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J Plant Physiol 167:12981306

During DNA replication, 8-oxoGua can adopt a syn-conformation and mispair with adenine (A), which, after two replication cycles, yields G:C to T:A transversions, a mutational signature frequently detected in HCC [31]

The catalytic site of GGT consists of two successive regions: Well-characterized donor site, specifying the substrates to which donor -glutamyl groups bind, and the acceptor site, about which little is currently known regarding the involved residues (24)