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Conversely, [U- 13 C]glucose tracing showed GGCT overexpression enhanced Glc-derived carbon flux into the TCA cycle (increased m + 2 labeling of succinate, fumarate, malate), which was reversed by the E98A mutant (Fig

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Unlike earlier reviews, this synthesis integrates historical context, current applications, mechanistic insights, safety considerations, and future prospects to provide a holistic perspective

Astrocytes are central to the brain maintenance through (1) controlling ionostasis of major ions (Na + , K + , Ca 2+ and Cl ) that define neuronal excitability